Laboratory biomarkers associated with COVID-19 severity and management.
Identifieur interne : 000125 ( Main/Exploration ); précédent : 000124; suivant : 000126Laboratory biomarkers associated with COVID-19 severity and management.
Auteurs : S. Keddie [Royaume-Uni] ; O. Ziff [Royaume-Uni] ; M K L. Chou [Royaume-Uni] ; R L Taylor [Royaume-Uni] ; A. Heslegrave [Royaume-Uni] ; E. Garr [Royaume-Uni] ; N. Lakdawala [Royaume-Uni] ; A. Church [Royaume-Uni] ; D. Ludwig [Royaume-Uni] ; J. Manson [Royaume-Uni] ; M. Scully [Royaume-Uni] ; E. Nastouli [Royaume-Uni] ; M D Chapman [Royaume-Uni] ; M. Hart [Royaume-Uni] ; M P Lunn [Royaume-Uni]Source :
- Clinical immunology (Orlando, Fla.) [ 1521-7035 ] ; 2020.
Abstract
The heterogeneous disease course of COVID-19 is unpredictable, ranging from mild self-limiting symptoms to cytokine storms, acute respiratory distress syndrome (ARDS), multi-organ failure and death. Identification of high-risk cases will enable appropriate intervention and escalation. This study investigates the routine laboratory tests and cytokines implicated in COVID-19 for their potential application as biomarkers of disease severity, respiratory failure and need of higher-level care. From analysis of 203 samples, CRP, IL-6, IL-10 and LDH were most strongly correlated with the WHO ordinal scale of illness severity, the fraction of inspired oxygen delivery, radiological evidence of ARDS and level of respiratory support (p ≤ 0.001). IL-6 levels of ≥3.27 pg/ml provide a sensitivity of 0.87 and specificity of 0.64 for a requirement of ventilation, and a CRP of ≥37 mg/l of 0.91 and 0.66. Reliable stratification of high-risk cases has significant implications on patient triage, resource management and potentially the initiation of novel therapies in severe patients.
DOI: 10.1016/j.clim.2020.108614
PubMed: 33153974
PubMed Central: PMC7581344
Affiliations:
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Scully</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology, University College London Hospitals NHS Foundation Trust and Cardiometabolic Programme-NIHR UCLH/UC BRC, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University College London Hospitals NHS Foundation Trust and Cardiometabolic Programme-NIHR UCLH/UC BRC, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nastouli, E" sort="Nastouli, E" uniqKey="Nastouli E" first="E" last="Nastouli">E. 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Hart</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lunn, M P" sort="Lunn, M P" uniqKey="Lunn M" first="M P" last="Lunn">M P Lunn</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33153974</idno><idno type="pmid">33153974</idno><idno type="doi">10.1016/j.clim.2020.108614</idno><idno type="pmc">PMC7581344</idno><idno type="wicri:Area/Main/Corpus">000049</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000049</idno><idno type="wicri:Area/Main/Curation">000049</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000049</idno><idno type="wicri:Area/Main/Exploration">000049</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Laboratory biomarkers associated with COVID-19 severity and management.</title><author><name sortKey="Keddie, S" sort="Keddie, S" uniqKey="Keddie S" first="S" last="Keddie">S. Keddie</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK. Electronic address: stephen.keddie@nhs.net.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ziff, O" sort="Ziff, O" uniqKey="Ziff O" first="O" last="Ziff">O. Ziff</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chou, M K L" sort="Chou, M K L" uniqKey="Chou M" first="M K L" last="Chou">M K L. Chou</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Taylor, R L" sort="Taylor, R L" uniqKey="Taylor R" first="R L" last="Taylor">R L Taylor</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Heslegrave, A" sort="Heslegrave, A" uniqKey="Heslegrave A" first="A" last="Heslegrave">A. Heslegrave</name><affiliation wicri:level="4"><nlm:affiliation>UK Dementia Research Institute, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UK Dementia Research Institute, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Garr, E" sort="Garr, E" uniqKey="Garr E" first="E" last="Garr">E. Garr</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lakdawala, N" sort="Lakdawala, N" uniqKey="Lakdawala N" first="N" last="Lakdawala">N. Lakdawala</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Church, A" sort="Church, A" uniqKey="Church A" first="A" last="Church">A. Church</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ludwig, D" sort="Ludwig, D" uniqKey="Ludwig D" first="D" last="Ludwig">D. Ludwig</name><affiliation wicri:level="3"><nlm:affiliation>Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Rheumatology, University College London Hospitals NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Manson, J" sort="Manson, J" uniqKey="Manson J" first="J" last="Manson">J. Manson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Rheumatology, University College London Hospitals NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Scully, M" sort="Scully, M" uniqKey="Scully M" first="M" last="Scully">M. Scully</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology, University College London Hospitals NHS Foundation Trust and Cardiometabolic Programme-NIHR UCLH/UC BRC, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University College London Hospitals NHS Foundation Trust and Cardiometabolic Programme-NIHR UCLH/UC BRC, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nastouli, E" sort="Nastouli, E" uniqKey="Nastouli E" first="E" last="Nastouli">E. Nastouli</name><affiliation wicri:level="3"><nlm:affiliation>Infection control department, University College London Hospitals NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Infection control department, University College London Hospitals NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chapman, M D" sort="Chapman, M D" uniqKey="Chapman M" first="M D" last="Chapman">M D Chapman</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hart, M" sort="Hart, M" uniqKey="Hart M" first="M" last="Hart">M. Hart</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lunn, M P" sort="Lunn, M P" uniqKey="Lunn M" first="M P" last="Lunn">M P Lunn</name><affiliation wicri:level="3"><nlm:affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Clinical immunology (Orlando, Fla.)</title><idno type="eISSN">1521-7035</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The heterogeneous disease course of COVID-19 is unpredictable, ranging from mild self-limiting symptoms to cytokine storms, acute respiratory distress syndrome (ARDS), multi-organ failure and death. Identification of high-risk cases will enable appropriate intervention and escalation. This study investigates the routine laboratory tests and cytokines implicated in COVID-19 for their potential application as biomarkers of disease severity, respiratory failure and need of higher-level care. From analysis of 203 samples, CRP, IL-6, IL-10 and LDH were most strongly correlated with the WHO ordinal scale of illness severity, the fraction of inspired oxygen delivery, radiological evidence of ARDS and level of respiratory support (p ≤ 0.001). IL-6 levels of ≥3.27 pg/ml provide a sensitivity of 0.87 and specificity of 0.64 for a requirement of ventilation, and a CRP of ≥37 mg/l of 0.91 and 0.66. Reliable stratification of high-risk cases has significant implications on patient triage, resource management and potentially the initiation of novel therapies in severe patients.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">33153974</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1521-7035</ISSN><JournalIssue CitedMedium="Internet"><Volume>221</Volume><PubDate><Year>2020</Year><Month>12</Month></PubDate></JournalIssue><Title>Clinical immunology (Orlando, Fla.)</Title><ISOAbbreviation>Clin Immunol</ISOAbbreviation></Journal><ArticleTitle>Laboratory biomarkers associated with COVID-19 severity and management.</ArticleTitle><Pagination><MedlinePgn>108614</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1521-6616(20)30774-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.clim.2020.108614</ELocationID><Abstract><AbstractText>The heterogeneous disease course of COVID-19 is unpredictable, ranging from mild self-limiting symptoms to cytokine storms, acute respiratory distress syndrome (ARDS), multi-organ failure and death. Identification of high-risk cases will enable appropriate intervention and escalation. This study investigates the routine laboratory tests and cytokines implicated in COVID-19 for their potential application as biomarkers of disease severity, respiratory failure and need of higher-level care. From analysis of 203 samples, CRP, IL-6, IL-10 and LDH were most strongly correlated with the WHO ordinal scale of illness severity, the fraction of inspired oxygen delivery, radiological evidence of ARDS and level of respiratory support (p ≤ 0.001). IL-6 levels of ≥3.27 pg/ml provide a sensitivity of 0.87 and specificity of 0.64 for a requirement of ventilation, and a CRP of ≥37 mg/l of 0.91 and 0.66. Reliable stratification of high-risk cases has significant implications on patient triage, resource management and potentially the initiation of novel therapies in severe patients.</AbstractText><CopyrightInformation>Crown Copyright © 2020. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Keddie</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK. Electronic address: stephen.keddie@nhs.net.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ziff</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chou</LastName><ForeName>M K L</ForeName><Initials>MKL</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>R L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heslegrave</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>UK Dementia Research Institute, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garr</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lakdawala</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Church</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ludwig</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manson</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scully</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Haematology, University College London Hospitals NHS Foundation Trust and Cardiometabolic Programme-NIHR UCLH/UC BRC, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nastouli</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Infection control department, University College London Hospitals NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chapman</LastName><ForeName>M D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hart</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lunn</LastName><ForeName>M P</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Neuroimmunology and CSF laboratory, University College London Hospitals NHS Trust National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Immunol</MedlineTA><NlmUniqueID>100883537</NlmUniqueID><ISSNLinking>1521-6616</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Biomarkers</Keyword><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">CRP</Keyword><Keyword MajorTopicYN="Y">Cytokines</Keyword><Keyword MajorTopicYN="Y">IL-10</Keyword><Keyword MajorTopicYN="Y">IL-6</Keyword><Keyword MajorTopicYN="Y">Intensive care</Keyword><Keyword MajorTopicYN="Y">LDH</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>10</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>10</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>11</Month><Day>6</Day><Hour>5</Hour><Minute>49</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33153974</ArticleId><ArticleId IdType="pii">S1521-6616(20)30774-9</ArticleId><ArticleId IdType="doi">10.1016/j.clim.2020.108614</ArticleId><ArticleId IdType="pmc">PMC7581344</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Keddie, S" sort="Keddie, S" uniqKey="Keddie S" first="S" last="Keddie">S. Keddie</name></region><name sortKey="Chapman, M D" sort="Chapman, M D" uniqKey="Chapman M" first="M D" last="Chapman">M D Chapman</name><name sortKey="Chou, M K L" sort="Chou, M K L" uniqKey="Chou M" first="M K L" last="Chou">M K L. Chou</name><name sortKey="Church, A" sort="Church, A" uniqKey="Church A" first="A" last="Church">A. Church</name><name sortKey="Garr, E" sort="Garr, E" uniqKey="Garr E" first="E" last="Garr">E. Garr</name><name sortKey="Hart, M" sort="Hart, M" uniqKey="Hart M" first="M" last="Hart">M. Hart</name><name sortKey="Heslegrave, A" sort="Heslegrave, A" uniqKey="Heslegrave A" first="A" last="Heslegrave">A. Heslegrave</name><name sortKey="Lakdawala, N" sort="Lakdawala, N" uniqKey="Lakdawala N" first="N" last="Lakdawala">N. Lakdawala</name><name sortKey="Ludwig, D" sort="Ludwig, D" uniqKey="Ludwig D" first="D" last="Ludwig">D. Ludwig</name><name sortKey="Lunn, M P" sort="Lunn, M P" uniqKey="Lunn M" first="M P" last="Lunn">M P Lunn</name><name sortKey="Manson, J" sort="Manson, J" uniqKey="Manson J" first="J" last="Manson">J. Manson</name><name sortKey="Nastouli, E" sort="Nastouli, E" uniqKey="Nastouli E" first="E" last="Nastouli">E. Nastouli</name><name sortKey="Scully, M" sort="Scully, M" uniqKey="Scully M" first="M" last="Scully">M. Scully</name><name sortKey="Taylor, R L" sort="Taylor, R L" uniqKey="Taylor R" first="R L" last="Taylor">R L Taylor</name><name sortKey="Ziff, O" sort="Ziff, O" uniqKey="Ziff O" first="O" last="Ziff">O. Ziff</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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